Diethylamine → (2S)-2-amino-5-(((tert-butoxy)carbonyl)amino)pentanoic acid

HRID 11860

반응식

HRID 11860 반응식
C([NH:18][C@H:19]([C:31]([OH:33])=[O:32])[CH2:20][CH2:21][CH2:22][NH:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O.C(NCC)C>CN(C=O)C>[C:24]([NH:23][CH2:22][CH2:21][CH2:20][C@@H:19]([C:31]([OH:33])=[O:32])[NH2:18])([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25]

참가 물질

4

반응물 2

HCID 8021DiethylamineHCID 2756114Fmoc-Orn(Boc)-OH

생성물 1

HCID 6993436(2S)-2-amino-5-(((tert-butoxy)carbonyl)amino)pentanoic acid수율 210%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The compound obtained in Example 23-1 (250.8 mg) was dissolved in DMF (5 ml). After the addition of diethylamine. (0.5 ml), the mixture was stirred for 2 hours at room temperature. After the reaction, the solvent was removed by distillation under reduced pressure and the residue was dried under vacuum to obtain the title compound (269.1 mg).

후처리

  1. customAfter the reaction
  2. customthe solvent was removed by distillation under reduced pressure
  3. customthe residue was dried under vacuum

출처 및 근거

ORD 기록
ord-4dc70e910fce4c9ba040b32abaa97152
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098215B2

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