Ethyl Acetate → 2-(Pyridin-3-yl)propan-2-ol

HRID 1186354노트

반응식

HRID 1186354 반응식
C[Mg]Br.[C:4]([C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)(=[O:6])[CH3:5].[Cl-].[NH4+].[C:15](OCC)(=O)C>O1CCCC1>[OH:6][C:4]([C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)([CH3:15])[CH3:5]

참가 물질

6

반응물 4

HCID 8857Ethyl AcetateHCID 95893-AcetylpyridineHCID 25517Ammonium ChlorideHCID 178418573HCID 178418573, 화합물

생성물 1

HCID 107254032-(Pyridin-3-yl)propan-2-ol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To methylmagnesium bromide (a 0.96 mol/L solution in tetrahydrofuran, 6.26 mL, 5.97 mmol), a solution of 3-acetylpyridine (362 mg, 2.99 mmol) in tetrahydrofuran (3.6 mL) was slowly added under a nitrogen atmosphere at 0° C., and the mixture was stirred at the same temperature for 1. Then, a saturated aqueous ammonium chloride solution was added to the reaction mixture, and extraction with ethyl acetate was performed, followed by washing with brine and drying over anhydrous sodium sulfate. The solvent was evaporated off under reduced pressure, and thereby 3-(1-hydroxy-1-methylethyl)pyridine (Compound DG) (415 mg, yield: quantitative) was obtained.

후처리

  1. washby washing with brine
  2. dry with materialdrying over anhydrous sodium sulfate
  3. customThe solvent was evaporated off under reduced pressure

출처 및 근거

ORD 기록
ord-9d93b4c14a4a40478e6c813c0675fa68
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673908B2

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