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2-Thiophenecarboxaldehyde → 2-Thiophenemethanol, a-(trifluoromethyl)-

HRID 1186362
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HRID 1186362 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=[O:7].C(=O)([O-])[O-].[K+].[K+].[F:14][C:15]([Si](C)(C)C)([F:17])[F:16]>O1CCCC1.CN(C)C=O>[F:14][C:15]([F:17])([F:16])[CH:6]([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[OH:7]
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참가 물질

6

반응물 3

HCID 73642-ThiophenecarboxaldehydeHCID 11430Potassium CarbonateHCID 552549(Trifluoromethyl)trimethylsilane

생성물 1

HCID 109541472-Thiophenemethanol, a-(trifluoromethyl)-수율 78%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8028Tetrahydrofuran용매

실험 절차

According to Reference Example 8-2, by use of thiophene-2-carbaldehyde (300 mg, 2.67 mmol) dissolved in tetrahydrofuran (4.5 mL) and N,N-dimethylformamide (1.5 mL), potassium carbonate (74 mg, 0.53 mmol) and (trifluoromethyl)trimethylsilane (0.772 mL, 5.34 mmol), the mixture was stirred and reacted at room temperature for 16 hours. Then, purification by extraction gave 2,2,2-trifluoro-1-(thiophen-2-yl)ethanol (Compound DN) (378 mg, yield: 78%).

후처리

  1. customreacted at room temperature for 16 hours
  2. customThen, purification
  3. extractionby extraction

출처 및 근거

ORD 기록
ord-f824ac6d7e3b4dc39c2a1b04ff792bfc
출처 데이터셋
uspto-grants-2014_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08673908B2

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