Potassium Carbonate → HCID 67401954, 화합물

HRID 1186371

반응식

HRID 1186371 반응식
[Cl:1][C:2]1[S:3][C:4]([CH:7]=[O:8])=[CH:5][N:6]=1.C(=O)([O-])[O-].[K+].[K+].[F:15][C:16]([Si](C)(C)C)([F:18])[F:17]>CN(C)C=O>[Cl:1][C:2]1[S:3][C:4]([CH:7]([OH:8])[C:16]([F:18])([F:17])[F:15])=[CH:5][N:6]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 552549(Trifluoromethyl)trimethylsilaneHCID 14797652-Chloro-1,3-thiazole-5-carbaldehyde

생성물 1

HCID 67401954HCID 67401954, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

According to Reference Example 8-2, by use of 2-chlorothiazole-5-carbaldehyde (300 mg, 2.03 mmol) dissolved in N,N-dimethylformamide (4 mL), potassium carbonate (56 mg, 0.41 mmol) and (trifluoromethyl)trimethylsilane (0.360 mL, 2.44 mmol), the mixture was stirred and reacted at room temperature for 1.3 hours. Then, purification by preparative thin-layer chromatography (chloroform/methanol=15/1) was performed to give

후처리

  1. customreacted at room temperature for 1.3 hours
  2. customThen, purification by preparative thin-layer chromatography (chloroform/methanol=15/1)
  3. customto give

출처 및 근거

ORD 기록
ord-9fb403dcf9c6448d8721f7ff0532fff1
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673908B2

연결된 노트

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