Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 2,2,2-Trifluoro-1-(2-morpholinothiazol-5-yl)ethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | (Trifluoromethyl)trimethylsilane | HCID 552549 | — |
| 반응물 | 2-(Morpholin-4-yl)-1,3-thiazole-5-carbaldehyde | HCID 1479770 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2,2,2-Trifluoro-1-(2-morpholinothiazol-5-yl)ethanol | HCID 67401740 | 65.1% |
반응 단계
According to Reference Example 8-2, by use of 2-morpholinothiazole-5-carbaldehyde (177 mg, 0.893 mmol) dissolved in N,N-dimethylformamide (5.3 mL), potassium carbonate (25 mg, 0.18 mmol) and (trifluoromethyl)trimethylsilane (0.198 mL, 1.34 mmol), the mixture was stirred and reacted at room temperature for 2.3 hours. Then, purification by preparative thin-layer chromatography (chloroform/methanol=15/1) was performed to give 2,2,2-trifluoro-1-(2-morpholinothiazol-5-yl)ethanol (Compound DY) (156 mg, yield: 65%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08673908B2 |
| 출처 데이터셋 | uspto-grants-2014_03 |
| ORD ID | ord-c2161b8b710a4619b109609db1ebd983 |
| 출처 메모 | uspto-grants-2014_03 |