(Trifluoromethyl)trimethylsilane → 2,2,2-Trifluoro-1-(4-methyloxan-4-yl)ethan-1-ol
반응식
[CH3:1][C:2]1([CH:8]=[O:9])[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1.[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[F:28][C:29]([Si](C)(C)C)([F:31])[F:30]>O1CCCC1>[F:28][C:29]([F:31])([F:30])[CH:8]([C:2]1([CH3:1])[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1)[OH:9]참가 물질
5
실험 절차
According to Reference Example 8-12, by use of 4-methyltetrahydro-2H-pyran-4-carbaldehyde (165 mg, 1.29 mmol) dissolved in tetrahydrofuran (5 mL), a 1 mol/L solution of tetrabutylammonium fluoride in tetrahydrofuran (0.258 mL, 0.258 mmol) and (trifluoromethyl)trimethylsilane (0.229 mL, 1.55 mmol), the mixture was stirred and reacted at room temperature for 1.7 hours. Then, purification by extraction gave 2,2,2-trifluoro-1-(4-methyltetrahydro-2H-pyran-4-yl)ethanol (Compound EC) (119 mg, yield: 47%).
후처리
- customreacted at room temperature for 1.7 hours
- customThen, purification
- extractionby extraction
출처 및 근거
- ORD 기록
- ord-1c629aebad5f45d1bae09b6c75e861ac
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08673908B2
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