3-Pyridinepropanol → 3-(Pyridin-3-yl)propanal

HRID 1186391

반응식

HRID 1186391 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH2:9][OH:10])[CH:2]=1.CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>ClCCl>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH:9]=[O:10])[CH:2]=1

참가 물질

4

반응물 2

HCID 178613-PyridinepropanolHCID 159087Triacetoxyperiodinane

생성물 1

HCID 111054123-(Pyridin-3-yl)propanal수율 61%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3-Pyridinepropanol (300 mg, 2.2 mmol) was dissolved in dichloromethane (5 mL). To this, the Dess-Martin reagent (1.0 g) was added with cooling in an ice bath and the mixture was stirred at the same temperature for 2 hours and successively at room temperature for 3 hours. The solvent in the reaction mixture was evaporated off under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform/methanol=1/0 to 10/1) to give 3-(pyridin-3-yl)propanal (180 mg, yield: 61%).

후처리

  1. temperaturewith cooling in an ice bath
  2. customThe solvent in the reaction mixture was evaporated off under reduced pressure
  3. customthe residue was purified by silica gel column chromatography (chloroform/methanol=1/0 to 10/1)

출처 및 근거

ORD 기록
ord-d0c2e372d0714bb590a9d46cd7f14c27
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673908B2

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