Ammonia → 2,4-Dimethylthiazole-5-sulfonamide

HRID 1186437노트

반응식

HRID 1186437 반응식
[CH3:1][C:2]1[S:3][C:4]([S:8](Cl)(=[O:10])=[O:9])=[C:5]([CH3:7])[N:6]=1.[NH3:12]>CO>[CH3:1][C:2]1[S:3][C:4]([S:8]([NH2:12])(=[O:10])=[O:9])=[C:5]([CH3:7])[N:6]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 2776248Dimethyl-1,3-thiazole-5-sulfonyl chloride

생성물 1

HCID 128731882,4-Dimethylthiazole-5-sulfonamide수율 34%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

According to Reference Example 9-7, by use of 2,4-dimethylthiazole-5-sulfonyl chloride (250 mg, 1.1 mmol) and a 7 mol/L solution of ammonia in methanol (2 mL), the mixture was stirred and reacted at room temperature for 2 hours. Then, purification by silica gel column chromatography (chloroform/methanol=1/0 to 20/1) was performed to give 2,4-dimethylthiazole-5-sulfonamide (Compound FL) (60 mg, yield: 34%).

후처리

  1. customreacted at room temperature for 2 hours
  2. customThen, purification by silica gel column chromatography (chloroform/methanol=1/0 to 20/1)

출처 및 근거

ORD 기록
ord-13b3e91a772c45de955e504fea7db96c
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673908B2

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