Ammonia → Cyclohexanesulfonamide

HRID 1186439노트

반응식

[CH:1]1([S:7](Cl)(=[O:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH3:11]>>[CH:1]1([S:7]([NH2:11])(=[O:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

반응물 2

HCID 222Ammonia

HCID 237554Cyclohexanesulfonyl chloride

생성물 1

HCID 75536Cyclohexanesulfonamide수율 60%

실험 절차

According to Reference Example 9-19, by use of cyclohexanesulfonyl chloride (300 mg, 1.6 mmol) and a 25% aqueous ammonia solution (2 mL), the mixture was stirred and reacted at room temperature for 18 hours. Then, purification by silica gel column chromatography (chloroform/methanol=1/0 to 20/1) was performed to give cyclohexanesulfonamide (Compound FW) (161 mg, yield: 60%).

후처리

customreacted at room temperature for 18 hours
customThen, purification by silica gel column chromatography (chloroform/methanol=1/0 to 20/1)

출처 및 근거

ORD 기록: ord-2b9a908a56cf4d7cbeeded1199c1c223
출처 데이터셋: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08673908B2

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