Morpholine → [3-(2-Morpholin-4-yl-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-piperidin-4-yl-amine
반응식
Br[C:2]1[N:6]2[CH:7]=[CH:8][N:9]=[C:10](Cl)[C:5]2=[N:4][CH:3]=1.C(OC([N:19]1[CH2:24][CH2:23][CH:22]([NH2:25])[CH2:21][CH2:20]1)=O)(C)(C)C.CS[C:28]1[N:33]=[C:32]([Sn](CCCC)(CCCC)CCCC)[CH:31]=[CH:30][N:29]=1.[NH:47]1[CH2:52][CH2:51][O:50][CH2:49][CH2:48]1>>[N:47]1([C:28]2[N:29]=[C:30]([C:2]3[N:6]4[CH:7]=[CH:8][N:9]=[C:10]([NH:25][CH:22]5[CH2:21][CH2:20][NH:19][CH2:24][CH2:23]5)[C:5]4=[N:4][CH:3]=3)[CH:31]=[CH:32][N:33]=2)[CH2:52][CH2:51][O:50][CH2:49][CH2:48]1참가 물질
5
실험 절차
[3-(2-Morpholin-4-yl-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-piperidin-4-yl-amine was prepared by a process analogous to that described in Example 12 starting from 3-bromo-8-chloro-imidazo[1,2-a]pyrazine (from Example 1 supra), 4-amino-piperidine-1-carboxylic acid tert-butyl ester, 2-methylsulfanyl-4-tributylstannanyl-pyrimidine, and morpholine. LC-MS: [M+H]+ 381.3.
출처 및 근거
- ORD 기록
- ord-3f8f9451e61a4240a145eec4f1079e51
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08673905B2
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