Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Methylthio)-4-(tributylstannyl)pyrimidine → 4-{4-[8-(2-Methanesulfonyl-ethylamino)-imidazo[1,2-a]pyrazin-3-yl]-pyrimidin-2-ylamino}-cyclohexanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Methylthio)-4-(tributylstannyl)pyrimidine | HCID 2763261 | — |
| 반응물 | (3-Bromo-imidazo[1,2-a]pyrazin-8-yl)-(2-methanesulfonyl-ethyl)-carbamic acid tert-butyl ester | HCID 68226902 | — |
| 반응물 | HCID 178511715 | HCID 178511715 | — |
| 생성물 | 4-{4-[8-(2-Methanesulfonyl-ethylamino)-imidazo[1,2-a]pyrazin-3-yl]-pyrimidin-2-ylamino}-cyclohexanol | HCID 66548262 | — |
반응 단계
4-{4-[8-(2-Methanesulfonyl-ethylamino)-imidazo[1,2-a]pyrazin-3-yl]-pyrimidin-2-ylamino}-cyclohexanol was prepared by a process analogous to that described in Example 12 starting from (3-bromo-imidazo[1,2-a]pyrazin-8-yl)-(2-methanesulfonyl-ethyl)-carbamic acid tert-butyl ester (from Example 5 supra), 2-methylsulfanyl-4-tributylstannanyl-pyrimidine, and trans-4-amino-cyclohexanol. LC-MS: [M+H]+ 432.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08673905B2 |
| 출처 데이터셋 | uspto-grants-2014_03 |
| ORD ID | ord-bbeb48f466b94c14bafdec5df9e7f379 |
| 출처 메모 | uspto-grants-2014_03 |