반응식
Br[C:2]1[N:6]2[CH:7]=[CH:8][N:9]=[C:10]([NH:11][CH2:12][CH2:13][OH:14])[C:5]2=[N:4][CH:3]=1.CS[C:17]1[N:22]=[C:21]([Sn](CCCC)(CCCC)CCCC)[CH:20]=[CH:19][N:18]=1.[NH2:36][CH:37]1[CH2:42][CH2:41][O:40][CH2:39][CH2:38]1>>[O:40]1[CH2:41][CH2:42][CH:37]([NH:36][C:17]2[N:18]=[C:19]([C:2]3[N:6]4[CH:7]=[CH:8][N:9]=[C:10]([NH:11][CH2:12][CH2:13][OH:14])[C:5]4=[N:4][CH:3]=3)[CH:20]=[CH:21][N:22]=2)[CH2:38][CH2:39]1참가 물질
4
실험 절차
2-{3-[2-(Tetrahydro-pyran-4-ylamino)-pyrimidin-4-yl]-imidazo[1,2-a]pyrazin-8-ylamino}-ethanol was prepared by a process analogous to that described in Example 12 starting from 2-(3-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-ethanol (from Example 2 supra), 2-methylsulfanyl-4-tributylstannanyl-pyrimidine, and 4-amino-tetrahydropyran. LC-MS: [M+H]+ 356.3.
출처 및 근거
- ORD 기록
- ord-7c293091818d4a45b19abed0a403d574
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08673905B2
연결된 노트
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