Water → HCID 86670920, 화합물

HRID 1186493노트

반응식

HRID 1186493 반응식
[Br:1][C:2]1[N:7]=[C:6]([C:8]2[N:12]3[CH:13]=[CH:14][N:15]=[C:16](Cl)[C:11]3=[N:10][CH:9]=2)[CH:5]=[CH:4][CH:3]=1.[N:18]1([CH2:24][CH2:25][NH2:26])[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1.CCN(CC)CC.O>CC(O)C>[Br:1][C:2]1[N:7]=[C:6]([C:8]2[N:12]3[CH:13]=[CH:14][N:15]=[C:16]([NH:26][CH2:25][CH2:24][N:18]4[CH2:23][CH2:22][O:21][CH2:20][CH2:19]4)[C:11]3=[N:10][CH:9]=2)[CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 4082852-MorpholinoethylamineHCID 86670917HCID 86670917, 화합물

생성물 1

HCID 86670920HCID 86670920, 화합물

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A mixture of 3-(6-bromo-pyridin-2-yl)-8-chloro-imidazo[1,2-a]pyrazine (from Example 38 supra) (3.09 g, 10.0 mmol), 2-morpholin-4-yl-ethylamine (2.6 g, 20.0 mmol), NEt3 (2.02 g, 20.0 mmol) in 2-propanol (300 mL) was stirred and heated at reflux for 16 hours. The solution was then cooled to room temperature and poured into water. The resulted solid was filtered and washed with water. The crude product was purified by chromatography (CH2Cl2:CH3OH, 20:1) to give [3-(6-bromo-pyridin-2-yl)-imidazo[1,2-a]pyrazin-8-yl]-(2-morpholin-4-yl-ethyl)-amine. (Yield 2.5 g, 62%). LC-MS: [M+H]+ 403.

후처리

  1. temperatureheated
  2. temperatureat reflux for 16 hours
  3. filtrationThe resulted solid was filtered
  4. washwashed with water
  5. customThe crude product was purified by chromatography (CH2Cl2:CH3OH, 20:1)

출처 및 근거

ORD 기록
ord-487c966197a540cc8e558966c93f51ef
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673905B2

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