Water → tert-Butyl 5-(2-trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrole-2-carboxylate

HRID 1186775노트

반응식

HRID 1186775 반응식
Cl.[CH2:2]1[C:6]2[CH2:7][NH:8][CH2:9][C:5]=2[CH2:4][N:3]1[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11].C(N(CC)CC)C.[F:24][C:25]([F:36])([F:35])[C:26]1[CH:34]=[CH:33][CH:32]=[CH:31][C:27]=1[C:28](Cl)=[O:29].O>C(Cl)Cl>[F:24][C:25]([F:35])([F:36])[C:26]1[CH:34]=[CH:33][CH:32]=[CH:31][C:27]=1[C:28]([N:8]1[CH2:7][C:6]2[CH2:2][N:3]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:4][C:5]=2[CH2:9]1)=[O:29]

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 675612-(Trifluoromethyl)benzoyl chlorideHCID 45792433tert-butyl 1H,2H,3H,4H,5H,6H-pyrrolo(3,4-c)pyrrole-2-carboxylate hydrochloride

생성물 1

HCID 58075189tert-Butyl 5-(2-trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrole-2-carboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

tert-Butyl 3,4,5,6-tetrahydro-1H-pyrrolo[3,4-C]pyrrole-2-carboxylate hydrochloride (30 g, 121.6 mmol) was suspended in 700 ml of methylene chloride, triethylamine (50.7 ml, 364.8 mmol) was added with ice bath cooling, and 2-(trifluoromethyl)benzoyl chloride (25.22 ml, 171.2 mmol) was slowly added dropwise. The brown suspension was stirred for 2 h, in the course of which it was allowed to come to RT. The reaction mixture was admixed with water, and the organic phase was removed, dried and concentrated by rotary evaporation. The crude product (56.8 g) was converted further without purification.

후처리

  1. temperaturecooling
  2. customto come to RT
  3. customthe organic phase was removed
  4. customdried
  5. concentrationconcentrated by rotary evaporation
  6. customThe crude product (56.8 g) was converted further without purification

출처 및 근거

ORD 기록
ord-c8919835bd52435098e98114a3b10906
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673917B2

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