3,6-Dichloropyridazine → 4-(((6-Chloropyridazin-3-yl)oxy)methyl)thiazole

HRID 1186783

반응식

HRID 1186783 반응식
[Cl:1][C:2]1[N:3]=[N:4][C:5](Cl)=[CH:6][CH:7]=1.[S:9]1[CH:13]=[C:12]([CH2:14][OH:15])[N:11]=[CH:10]1>>[Cl:1][C:2]1[N:3]=[N:4][C:5]([O:15][CH2:14][C:12]2[N:11]=[CH:10][S:9][CH:13]=2)=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 673313,6-DichloropyridazineHCID 2763215(1,3-Thiazol-4-yl)methanol

생성물 1

HCID 580751834-(((6-Chloropyridazin-3-yl)oxy)methyl)thiazole

실험 절차

3,6-Dichloropyridazine (1.0 g, 6.712 mmol) was reacted analogously to example 4a with thiazol-4-ylmethanol (578 mg, 6.712 mmol). Yield: 775 mg (51%), M+H+: 228.0,

출처 및 근거

ORD 기록
ord-5be33caac55f43689225f0897cbb61f6
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673917B2

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