Methanol → 2-(Methyloxy)-4-(2-oxoethyl)benzonitrile
반응식
[CH3:1][O:2][C:3]1[CH:10]=[C:9]([CH2:11][CH:12]=C)[CH:8]=[CH:7][C:4]=1[C:5]#[N:6].CSC.C[OH:18]>>[CH3:1][O:2][C:3]1[CH:10]=[C:9]([CH2:11][CH:12]=[O:18])[CH:8]=[CH:7][C:4]=1[C:5]#[N:6]참가 물질
4
실험 절차
To a 25 mL flask containing a stir bar was added compound 2-(methyloxy)-4-prop-2-en-1-ylbenzonitrile (0.150 g, 0.866 mmol) and MeOH (8 mL). The flask was placed in a cold bath of −78° C. Ozone was bubbled through the flask for about 10 min. followed by addition of dimethyl sulfide (1.5 mL, 0.024 mmol). The flask was taken out of the cold bath and stirred at room temperature for 1 h; LC indicated completion of the reaction. The reaction mixture was concentrated to dryness to give 2-(methyloxy)-4-(2-oxoethyl)benzonitrile.
후처리
- additionTo a 25 mL flask containing a stir bar
- customThe flask was placed in a cold bath of −78° C
- customOzone was bubbled through the flask for about 10 min.
- customcompletion of the reaction
- concentrationThe reaction mixture was concentrated to dryness
출처 및 근거
- ORD 기록
- ord-2975c2feeac6445e80b8378997465885
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08673920B2
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