1,4-Dioxane hydrochloride → 1-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine

HRID 1187133노트

반응식

HRID 1187133 반응식
CC([CH:5]1[CH2:10][N:9]([CH2:11][CH:12]2[C:21]3[C:16](=[C:17]([Br:22])[CH:18]=[CH:19][CH:20]=3)[CH2:15][CH2:14][O:13]2)[CH2:8][CH2:7][N:6]1C([O-])=O)(C)C.Cl.O1CCOCC1>C(Cl)Cl>[Br:22][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:16]=1[CH2:15][CH2:14][O:13][CH:12]2[CH2:11][N:9]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:10]1

참가 물질

4

반응물 2

HCID 204431481,4-Dioxane hydrochlorideHCID 866473201,1-dimethylethyl-4-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine-1-carboxylate

생성물 1

HCID 666439161-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 1,1-dimethylethyl-4-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine-1-carboxylate (480 mg, 1.2 mmol) in 10 mL of DCM was added 10 mL of 4N HCl/dioxane, and then stirred at room temperature for 2 hours. The solvents was removed under vacuum to afford 1-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine.

후처리

  1. customThe solvents was removed under vacuum

출처 및 근거

ORD 기록
ord-4941a95b135245828ff81b3dc3310475
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673920B2

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