5-(benzyloxy)-2-methylpyridin-4(1H)-one → 5-hydroxy-2-methylpyridin-4(1H)-one

HRID 1187470노트

반응식

HRID 1187470 반응식
C([O:8][C:9]1[C:10](=[O:16])[CH:11]=[C:12]([CH3:15])[NH:13][CH:14]=1)C1C=CC=CC=1>CO.O.[Pd]>[OH:8][C:9]1[C:10](=[O:16])[CH:11]=[C:12]([CH3:15])[NH:13][CH:14]=1

참가 물질

5

반응물 1

HCID 63247195-(benzyloxy)-2-methylpyridin-4(1H)-one

생성물 1

HCID 6426495-hydroxy-2-methylpyridin-4(1H)-one수율 70.5%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution of 5-benzyloxy-2-methyl-1H-pyridin-4-one (2 g, 9.29 mmol) in methanol (30 ml) and water (8 ml) was placed in a Parr bottle. 10% Pd/C was added and the mixture was hydrogenated at 50 psi for 3 hours. A bed of CELITE™ was placed on a sintered glass, and washed with 0.1N HCl and then water. The content in the Parr bottle was removed from the Parr hydrogenator and flushed with nitrogen. The solution was filtered under suction. The filtrate was evaporated to give a white solid (820 mg, 70% yield).

후처리

  1. washwashed with 0.1N HCl
  2. customThe content in the Parr bottle was removed from the Parr hydrogenator
  3. customflushed with nitrogen
  4. filtrationThe solution was filtered under suction
  5. customThe filtrate was evaporated

출처 및 근거

ORD 기록
ord-2b44199cd4514f1d851c7ec6e91eaf55
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673943B2

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