HCID 67282369, 화합물 → HCID 25018649, 화합물

HRID 1187473노트

반응식

HRID 1187473 반응식
C([O:8][C:9]1[C:14](=[O:15])[C:13]([CH:16]([OH:21])[C:17]([F:20])([F:19])[F:18])=[CH:12][NH:11][C:10]=1[CH3:22])C1C=CC=CC=1.[H][H]>CO.[Pd]>[OH:8][C:9]1[C:14](=[O:15])[C:13]([CH:16]([OH:21])[C:17]([F:20])([F:18])[F:19])=[CH:12][NH:11][C:10]=1[CH3:22]

참가 물질

5

반응물 2

HCID 67282369HCID 67282369, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 25018649HCID 25018649, 화합물수율 84.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

3-benzyloxy-2-methyl-5-(2,2,2-trifluoro-1-hydroxy-ethyl)-1H-pyridin-4-one (0.5 g, 1.60 mmol) was dissolved in methanol and hydrogenated over 10% Pd/C for 3 hrs at 50 psi hydrogen on a Parr hydrogenator. The mixture was filtered through CELITE™ and the filtrate was evaporated to give a solid (300 mg, 84.2%).

후처리

  1. filtrationThe mixture was filtered through CELITE™
  2. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-ab23b81e9ea54b02b89d975d3da2c651
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673943B2

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