Ammonium Chloride → 4-(2-Fluorophenoxy)aniline

HRID 1187599노트

반응식

HRID 1187599 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=1.[NH4+].[Cl-]>CO.O.[Fe]>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=1

참가 물질

5

반응물 2

HCID 25517Ammonium ChlorideHCID 579749991-Fluoro-2-(4-nitrophenoxy)benzene

생성물 1

HCID 51260734-(2-Fluorophenoxy)aniline수율 73.4%

시약·촉매·용매 2

HCID 23925Iron촉매HCID 22242641Methanol--water (1/1)용매

실험 절차

Into a 250 mL 3-necked round-bottom flask, was placed a solution of 1-fluoro-2-(4-nitrophenoxy)benzene (5 g, 21.44 mmol, 1.00 equiv) in methanol/H2O (2/1=V/V) (100 mL), and NH4Cl (1 g, 18.70 mmol, 0.87 equiv). This was followed by the addition of Fe (7 g, 5.83 equiv), in portions at 80° C. in 20 min. The resulting solution was stirred for 1 h at reflux in an oil bath. The reaction mixture was cooled in a water bath. The solids were filtered out and the filtrate was concentrated under vacuum. The resulting solution was extracted with ethyl acetate and the organic layers combined and dried over anhydrous sodium sulfate and concentrated under vacuum to give 3.2 g (73%) of 4-(2-fluorophenoxy)aniline as a light yellow solid.

후처리

  1. customInto a 250 mL 3-necked round-bottom flask, was placed
  2. temperatureat reflux in an oil bath
  3. temperatureThe reaction mixture was cooled in a water bath
  4. filtrationThe solids were filtered out
  5. concentrationthe filtrate was concentrated under vacuum
  6. extractionThe resulting solution was extracted with ethyl acetate
  7. dry with materialdried over anhydrous sodium sulfate
  8. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-c88b51d48f844c24ae690677581d57e7
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673925B1

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