2-Amino-4-(4-chlorophenyl)thiazole → HCID 86674622, 화합물

HRID 1188131노트

반응식

HRID 1188131 반응식
[CH3:1][N:2](C1CCCCO1)[C:3]1[S:4][C:5]([CH:8]=O)=[CH:6][N:7]=1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[N:24]=[C:25]([NH2:28])[S:26][CH:27]=2)=[CH:19][CH:18]=1>>[ClH:16].[ClH:16].[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]2[N:24]=[C:25]([NH:28][CH2:8][C:5]3[S:4][C:3]([NH:2][CH3:1])=[N:7][CH:6]=3)[S:26][CH:27]=2)=[CH:21][CH:22]=1

참가 물질

3

반응물 2

HCID 732412-Amino-4-(4-chlorophenyl)thiazoleHCID 59408736HCID 59408736, 화합물

생성물 1

HCID 86674622HCID 86674622, 화합물

실험 절차

Compound 2aa was prepared as described for 2w starting from 2-(methyl-(tetrahydro-2H-pyran-2-yl)amino)thiazole-5-carbaldehyde and 4-(4-chloro phenyl)thiazol-2-amine: (30 mg, 77%). Mp. 122-123° C.

후처리

  1. customCompound 2aa was prepared

출처 및 근거

ORD 기록
ord-65e300d1fdea45b7ad8e478c83b386bd
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673940B2

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