Formaldehyde → 3-(3,5-Difluorophenyl)-3-methoxy-1-methyl pyrrolidine

HRID 1188162노트

반응식

HRID 1188162 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:9]2([O:14][CH3:15])[CH2:13][CH2:12][NH:11][CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1.[CH2:16]=O>C(O)=O>[F:1][C:2]1[CH:3]=[C:4]([C:9]2([O:14][CH3:15])[CH2:13][CH2:12][N:11]([CH3:16])[CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1

참가 물질

4

반응물 2

HCID 712FormaldehydeHCID 199358743-(3,5-Difluorophenyl)-3-methoxypyrrolidine

생성물 1

HCID 462192243-(3,5-Difluorophenyl)-3-methoxy-1-methyl pyrrolidine

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

Preparation according to Example 16. (−)-3-(3,5-difluorophenyl)-3-methoxypyrrolidine (0.02 g, 0.094 mmol), formic acid (1 ml) and formaldehyde (40% solution in water, 1 ml) was heated at 85° C. for 5 h, workup according to preparation 16. MS m/z (relative intensity, 70 eV) 227 (M+, 5), 212 (32), 197 (28), 141 (45), 57 (bp).

후처리

  1. customPreparation
  2. customworkup according to preparation 16

출처 및 근거

ORD 기록
ord-4b4e465cf41e4fa491eb6172a49988f7
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673962B2

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