m-Chloroperbenzoic acid → 3-(3,4-Difluorophenyl)-3-methoxy-1-methylpyrrolidine-1-oxide
반응식
[F:1][C:2]1[CH:3]=[C:4]([C:9]2([O:15][CH3:16])[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[F:8].ClC1C=C(C=CC=1)C(OO)=[O:22]>ClCCl>[F:1][C:2]1[CH:3]=[C:4]([C:9]2([O:15][CH3:16])[CH2:13][CH2:12][N+:11]([O-:22])([CH3:14])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[F:8]참가 물질
4
실험 절차
Preparation according to Example 32: Enantiomer 2 of 3-(3,4-difluorophenyl)-3-methoxy-1-methylpyrrolidine (0.012 g, 0.052 mmol), dichloromethane (2 ml), 3-chloroperoxybenzoic acid (77%) (0.023 g, 0.104 mmol). The crude product was analyzed by LCMS (Qtrap, Applied Biosystems, Q1 MS), analysis showed <95% conversion: MS (m+1)/z; 244 (M+1, bp), 243 (4), 214 (9), 150 (3).
후처리
- customPreparation
출처 및 근거
- ORD 기록
- ord-bc064d62d3ac49aaba12be9c0c8e4124
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08673962B2
반응 노트
불러오는 중…