Oxalyl chloride → 1,3-BENZOTHIAZOLE-6-CARBONYL CHLORIDE
반응식
[S:1]1[C:5]2[CH:6]=[C:7]([C:10]([OH:12])=O)[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.C(Cl)(=O)C([Cl:16])=O>C(Cl)Cl.CN(C)C=O>[S:1]1[C:5]2[CH:6]=[C:7]([C:10]([Cl:16])=[O:12])[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1참가 물질
5
반응 조건
- 온도
- 30 °C
실험 절차
Under a nitrogen atmosphere, benzothiazole-6-carboxylic acid (1.014 g, 5.6 mmol) was dissolved in methylene chloride (25 mL). Five drops of N,N-dimethylforamide was added. Oxalyl chloride (0.5 mL, 5.6 mmol) was slowly added. After 2 hrs, the reaction was heated to 30° C. for 16 hrs. The reaction was concentrated in vacuo to yield benzothiazole-6-carbonyl chloride (1.665 g, quant., light yellow powder)
후처리
- concentrationThe reaction was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-ce59087747534178b9332f6d9af5d54b
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08673961B2
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