2,5-Difluorobenzohydrazide → 1-{[5-(2,5-Difluorophenyl)-1,3,4-oxadiazol-2-yl]methyl}-4-(trifluoromethyl)-1H-indole-5-carbonitrile

HRID 1188408노트

반응식

HRID 1188408 반응식
[C:1]([C:3]1[C:4]([C:16]([F:19])([F:18])[F:17])=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][C:13]([OH:15])=O)[CH:7]=[CH:6]2)#[N:2].[F:20][C:21]1[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:22]=1[C:23]([NH:25][NH2:26])=O>>[F:20][C:21]1[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:22]=1[C:23]1[O:15][C:13]([CH2:12][N:8]2[C:9]3[C:5](=[C:4]([C:16]([F:19])([F:18])[F:17])[C:3]([C:1]#[N:2])=[CH:11][CH:10]=3)[CH:6]=[CH:7]2)=[N:26][N:25]=1

참가 물질

3

반응물 2

HCID 27740742,5-DifluorobenzohydrazideHCID 57800132[5-cyano-4-(trifluoromethyl)-1H-indol-1-yl]acetic acid

생성물 1

HCID 578002711-{[5-(2,5-Difluorophenyl)-1,3,4-oxadiazol-2-yl]methyl}-4-(trifluoromethyl)-1H-indole-5-carbonitrile

실험 절차

Synthesized as described in Example 35C from [5-cyano-4-(trifluoromethyl)-1H-indol-1-yl]acetic acid and 2,5-difluorobenzohydrazide: MS (ES) m/z 405 (M+1).

후처리

  1. customSynthesized

출처 및 근거

ORD 기록
ord-22ad36f7989044daabc222fc6eda7f48
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673948B2

반응 노트

불러오는 중…