2-Bromoacetamide → HCID 67404352, 화합물

반응식

[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([C:11]([F:14])([F:13])[F:12])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=2.Br[CH2:18][C:19]([NH2:21])=[O:20]>>[C:15]([C:7]1[C:8]([C:11]([F:12])([F:14])[F:13])=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]([CH2:18][C:19]([NH2:21])=[O:20])[C:2]([CH3:1])=[CH:10]2)#[N:16]

참가 물질

반응물 2

HCID 696322-Bromoacetamide

HCID 533093462-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

생성물 1

HCID 67404352HCID 67404352, 화합물

실험 절차

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile and 2-bromoacetamide: 1H NMR (400 MHz, DMSO-d6) δ 7.82 (d, J=8.5 Hz, 1H), 7.71 (bs, 1H), 7.67 (d, J=8.5 Hz, 1H), 7.35 (bs, 1H), 6.55 (s, 1H), 4.89 (s, 2H), 2.39 (s, 3H); MS (ES) m/z 282 (M+1).

후처리

customSynthesized

출처 및 근거

ORD 기록: ord-22618b7ff6c0464e9ac4d18e300e24b3
출처 데이터셋: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08673948B2

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