3-Bromo-5-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]pyridine → 1-{[5-(5-Bromo-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-(2-methylpropyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

참여 물질

역할	이름	HCID	투입량
반응물	3-Bromo-5-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]pyridine	HCID 28979365	—
반응물	2-(2-methylpropyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile	HCID 67405196	—
생성물	1-{[5-(5-Bromo-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-(2-methylpropyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile	HCID 67406971	—

반응 단계

Synthesized as described in Example 4 using 2-(2-methylpropyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile and 3-bromo-5-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]pyridine: 1H NMR (400 MHz, CDCl3) δ 9.04 (d, J=1.4 Hz, 1H), 8.84 (d, J=2.0 Hz, 1H), 8.43 (m, 1H), 7.68 (d, J=8.4 Hz, 1H), 7.59 (d, J=8.4 Hz, 1H), 6.67 (s, 1H), 5.63 (s, 2H), 2.82 (d, J=7.1 Hz, 2H), 2.13 (m, 1H), 1.08 (d, J=6.6 Hz, 6H); MS (ES) m/z 504 (M+1, isotope for Br) and 506 (M+1, isotope for Br).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08673948B2
출처 데이터셋	uspto-grants-2014_03
ORD ID	ord-35e5d8601d1c452c9614151d61f2c75d
출처 메모	uspto-grants-2014_03