Water → N-(4-Bromo-3-chloro-2-methylphenyl)acetamide
반응식
[Cl:1][C:2]1[C:3]([CH3:12])=[C:4]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1.[Br:13]Br.O>C(O)(=O)C>[Br:13][C:7]1[CH:6]=[CH:5][C:4]([NH:8][C:9](=[O:11])[CH3:10])=[C:3]([CH3:12])[C:2]=1[Cl:1]참가 물질
5
반응 조건
- 온도
- 10 °C
실험 절차
A suspension of N-(3-chloro-2-methylphenyl)acetamide (11.12 g, 60.63 mmol) in acetic acid (80 mL) was cooled to ca. 10° C. and then treated with bromine (9.28 mL, 181.11 mmol). The resulting mixture was stirred at rt for 2 h. The cooled solution was then poured into water (100 mL). The resulting solid was collected via filtration and rinsed with water. Thorough drying afforded 15.83 g of a pale yellow solid: MS (APCI) m/z 264 (M+2 isotope).
후처리
- filtrationThe resulting solid was collected via filtration
- washrinsed with water
- customThorough drying
출처 및 근거
- ORD 기록
- ord-f1133743ea624b9d97929e271ab0bdf6
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08673948B2
반응 노트
불러오는 중…