Water → N-(4-Bromo-3-chloro-2-methylphenyl)acetamide

HRID 1188519

반응식

HRID 1188519 반응식
[Cl:1][C:2]1[C:3]([CH3:12])=[C:4]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1.[Br:13]Br.O>C(O)(=O)C>[Br:13][C:7]1[CH:6]=[CH:5][C:4]([NH:8][C:9](=[O:11])[CH3:10])=[C:3]([CH3:12])[C:2]=1[Cl:1]

참가 물질

5

반응물 3

HCID 962WaterHCID 24408BromineHCID 81969N-(3-chloro-2-methylphenyl)acetamide

생성물 1

HCID 86376N-(4-Bromo-3-chloro-2-methylphenyl)acetamide수율 99.5%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
10 °C

실험 절차

A suspension of N-(3-chloro-2-methylphenyl)acetamide (11.12 g, 60.63 mmol) in acetic acid (80 mL) was cooled to ca. 10° C. and then treated with bromine (9.28 mL, 181.11 mmol). The resulting mixture was stirred at rt for 2 h. The cooled solution was then poured into water (100 mL). The resulting solid was collected via filtration and rinsed with water. Thorough drying afforded 15.83 g of a pale yellow solid: MS (APCI) m/z 264 (M+2 isotope).

후처리

  1. filtrationThe resulting solid was collected via filtration
  2. washrinsed with water
  3. customThorough drying

출처 및 근거

ORD 기록
ord-f1133743ea624b9d97929e271ab0bdf6
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673948B2

연결된 노트

불러오는 중…