3-(Chloromethyl)-5-(4-fluorophenyl)-1,2-oxazole → HCID 57800460, 화합물

반응식

[CH2:1]([C:4]1[NH:5][C:6]2[C:11]([CH:12]=1)=[C:10]([C:13]([F:16])([F:15])[F:14])[C:9]([C:17]#[N:18])=[CH:8][CH:7]=2)[CH2:2][CH3:3].Cl[CH2:20][C:21]1[CH:25]=[C:24]([C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=2)[O:23][N:22]=1>>[F:32][C:29]1[CH:28]=[CH:27][C:26]([C:24]2[O:23][N:22]=[C:21]([CH2:20][N:5]3[C:6]4[C:11](=[C:10]([C:13]([F:15])([F:16])[F:14])[C:9]([C:17]#[N:18])=[CH:8][CH:7]=4)[CH:12]=[C:4]3[CH2:1][CH2:2][CH3:3])[CH:25]=2)=[CH:31][CH:30]=1

참가 물질

반응물 2

HCID 166414733-(Chloromethyl)-5-(4-fluorophenyl)-1,2-oxazole

HCID 674051552-propyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

생성물 1

HCID 57800460HCID 57800460, 화합물

실험 절차

Synthesized in a manner similar to Example 23 using 2-propyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile and 3-(chloromethyl)-5-(4-fluorophenyl)isoxazole: MS (ES) m/z 428 (M+1).

출처 및 근거

ORD 기록: ord-20acead6cd6b4fab90548e6babfb591c
출처 데이터셋: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08673948B2

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