2-Bromo-4-(chloromethyl)thiazole → 1-[(2-Bromo-1,3-thiazol-4-yl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

HRID 1188627

반응식

HRID 1188627 반응식
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([C:11]([F:14])([F:13])[F:12])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=2.[Br:17][C:18]1[S:19][CH:20]=[C:21]([CH2:23]Cl)[N:22]=1>>[Br:17][C:18]1[S:19][CH:20]=[C:21]([CH2:23][N:3]2[C:4]3[C:9](=[C:8]([C:11]([F:12])([F:14])[F:13])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=3)[CH:10]=[C:2]2[CH3:1])[N:22]=1

참가 물질

3

반응물 2

HCID 164271492-Bromo-4-(chloromethyl)thiazoleHCID 533093462-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

생성물 1

HCID 674043581-[(2-Bromo-1,3-thiazol-4-yl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

실험 절차

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 2-bromo-4-(chloromethyl)-1,3-thiazole (Example 311A): MS (ES) m/z 400 (M+1) and 402 (M+1, isotope).

후처리

  1. customSynthesized

출처 및 근거

ORD 기록
ord-f523884cf3ee4dd98b51532bca6412a3
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673948B2

연결된 노트

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