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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1188629생성일: 2026년 10월 27일

(3,5-Difluorophenyl)boronic acid → 1-{[2-(3,5-Difluorophenyl)-1,3-thiazol-4-yl]methyl}-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/1188629

반응식

참여 물질

역할이름HCID투입량
반응물(3,5-Difluorophenyl)boronic acidHCID 2734338—
반응물1-[(2-Bromo-1,3-thiazol-4-yl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67404358—
생성물1-{[2-(3,5-Difluorophenyl)-1,3-thiazol-4-yl]methyl}-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67406112—

반응 단계

Synthesized as described in Example 310D using 1-[(2-bromo-1,3-thiazol-4-yl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 311B) and [3,5-difluorophenyl]boronic acid: MS (ES) m/z 434 (M+1).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08673948B2
출처 데이터셋uspto-grants-2014_03
ORD IDord-c6181caa779e40f8aae4e1aadfc73a7a
출처 메모uspto-grants-2014_03