3-Bromo-5-(chloromethyl)isoxazole → HCID 67406096, 화합물

HRID 1188649노트

반응식

HRID 1188649 반응식
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([C:11]([F:14])([F:13])[F:12])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=2.[Br:17][C:18]1[CH:22]=[C:21]([CH2:23]Cl)[O:20][N:19]=1>>[Br:17][C:18]1[CH:22]=[C:21]([CH2:23][N:3]2[C:4]3[C:9](=[C:8]([C:11]([F:12])([F:14])[F:13])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=3)[CH:10]=[C:2]2[CH3:1])[O:20][N:19]=1

참가 물질

3

반응물 2

HCID 27632033-Bromo-5-(chloromethyl)isoxazoleHCID 533093462-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

생성물 1

HCID 67406096HCID 67406096, 화합물

실험 절차

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 3-bromo-5-(chloromethyl)isoxazole (Example 325A): MS (ES) m/z 382 (M−1) and 384 (M−1, isotope).

후처리

  1. customSynthesized

출처 및 근거

ORD 기록
ord-946149b652254980aa086c1220a83c8d
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673948B2

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