Boron tribromide → HCID 67081467, 화합물

HRID 1188746노트

반응식

HRID 1188746 반응식
B(Br)(Br)Br.[I:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[S:13][C:14]3[CH:20]=[C:19]([O:21]C)[CH:18]=[CH:17][C:15]=3[N:16]=2)=[CH:8][CH:7]=1.C([O-])(O)=O.[Na+]>C(Cl)Cl>[I:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]2[S:13][C:14]3[CH:20]=[C:19]([OH:21])[CH:18]=[CH:17][C:15]=3[N:16]=2)=[CH:10][CH:11]=1

참가 물질

5

반응물 3

HCID 25134Boron tribromideHCID 516892Sodium BicarbonateHCID 67081740HCID 67081740, 화합물

생성물 1

HCID 67081467HCID 67081467, 화합물수율 55.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Boron tribromide (1 M in CH2Cl2, 6 mL) was added to an anhydrous CH2Cl2 (20 mL) solution of 4 (550 mg, 1.5 mmol). After stirring at room temperature for 24 h, the reaction mixture was quenched with ice water (10 mL) and neutralized with solid NaHCO3 (1.51 g, 18.0 mmol). The mixture was diluted with pH 7 buffer solution (Fisher, 20 mL) and extracted with dichloromethane-methanol (4:1, 3×100 mL). The extracts were combined, dried with anhydrous Na2SO4, and evaporated. The residue was treated with CH2Cl2/MeOH, to give pure 2-(4-iodophenyl)-1,3-benzothiazol-6-ol (5) as a white solid (295 mg, 55.8%).

후처리

  1. customthe reaction mixture was quenched with ice water (10 mL)
  2. extractionextracted with dichloromethane-methanol (4:1, 3×100 mL)
  3. dry with materialdried with anhydrous Na2SO4
  4. customevaporated
  5. additionThe residue was treated with CH2Cl2/MeOH

출처 및 근거

ORD 기록
ord-3e2288c7e9294c48b27b8db8561f7ea9
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08674101B2

반응 노트

불러오는 중…