2-Bromopyrimidine → 2-(4-Phenylbut-1-ynyl)pyrimidine

HRID 1189058노트

반응식

Br[C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH2:9][C:10]#[CH:11]>>[C:12]1([CH2:8][CH2:9][C:10]#[C:11][C:2]2[N:7]=[CH:6][CH:5]=[CH:4][N:3]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

반응물 2

HCID 783452-Bromopyrimidine

HCID 1233604-Phenyl-1-butyne

생성물 1

HCID 115430162-(4-Phenylbut-1-ynyl)pyrimidine수율 86%

실험 절차

The title compound was prepared in accordance with the general method of Example 1, from 2-bromopyrimidine (290 mg, 1.82 mmol) and 1-(but-3-ynyl)benzene (200 mg, 1.54 mmol). The crude residue was purified by flash chromatography (cyclohexane/AcOEt 85:15) to yield 275 mg (1.32 mmol, 86%) of 2-(4-phenylbut-1-ynyl)pyrimidine as a yellow oil.

후처리

customThe crude residue was purified by flash chromatography (cyclohexane/AcOEt 85:15)

출처 및 근거

ORD 기록: ord-3c831ec1c9d0439986fd9acb8130ada0
출처 데이터셋: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08674106B2

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