2,4-Dichloropyrimidine → 2-Chloro-4-(4-phenylbut-1-ynyl)pyrimidine

반응식

[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH2:9]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:10][C:11]#[CH:12]>>[Cl:1][C:2]1[N:7]=[C:6]([C:12]#[C:11][CH2:10][CH2:9][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:5]=[CH:4][N:3]=1

참가 물질

반응물 2

HCID 775312,4-Dichloropyrimidine

HCID 1233604-Phenyl-1-butyne

생성물 1

HCID 117014952-Chloro-4-(4-phenylbut-1-ynyl)pyrimidine수율 69%

실험 절차

The title compound was prepared in accordance with the general method of Example 1, from 2,4-dichloropyrimidine (250 mg, 1.68 mmol) and 1-(but-3-ynyl)benzene (218 mg, 1.68 mmol). The crude residue was purified by flash chromatography (cyclohexane/AcOEt 9:1) to yield 280 mg (1.15 mmol, 69%) of 2-chloro-4-(4-phenylbut-1-ynyl)pyrimidine as a brown oil.

후처리

customThe crude residue was purified by flash chromatography (cyclohexane/AcOEt 9:1)

출처 및 근거

ORD 기록: ord-34c29c83f350429dbf092033011124ff
출처 데이터셋: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08674106B2

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