2-Bromopyridine → HCID 11623276, 화합물

HRID 1189135노트

반응식

Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:8]([C:12]1[S:13][C:14]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[C:15]=2[N:16]=1)[CH2:9][C:10]#[CH:11]>>[CH3:21][C:17]1[C:15]2[N:16]=[C:12]([CH2:8][CH2:9][C:10]#[C:11][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=3)[S:13][C:14]=2[CH:20]=[CH:19][CH:18]=1

참가 물질

반응물 2

HCID 79732-Bromopyridine

HCID 86086866HCID 86086866, 화합물

생성물 1

HCID 11623276HCID 11623276, 화합물수율 25.4%

실험 절차

The title compound was prepared in accordance with the general method of Example 1, from 2-bromopyridine (193 mg, 1.22 mmol) and 2-but-3-ynyl-4-methyl-benzo[d]thiazole (246 mg, 1.22 mmol). The crude residue was purified by flash chromatography (DCM/MeOH 99:1 to 98:2) to yield 86 mg (0.31 mmol, 25%) of 4-methyl-2-(4-(pyridin-2-yl)but-3-ynyl)benzo[d]thiazole as a brown oil.

후처리

customThe crude residue was purified by flash chromatography (DCM/MeOH 99:1 to 98:2)

출처 및 근거

ORD 기록: ord-353690ebf0d743a3bd08f0c3dc55dd7f
출처 데이터셋: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08674106B2

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