Nitrogen → 5-(3-Fluoro-phenyl)-thiazole-4-carbonyl chloride

HRID 1189379노트

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HRID 1189379 반응식
N#N.[F:3][C:4]1[CH:5]=[C:6]([C:10]2[S:14][CH:13]=[N:12][C:11]=2[C:15]([OH:17])=O)[CH:7]=[CH:8][CH:9]=1.CN(C=O)C.C(Cl)(=O)C([Cl:26])=O>C1(C)C=CC=CC=1>[F:3][C:4]1[CH:5]=[C:6]([C:10]2[S:14][CH:13]=[N:12][C:11]=2[C:15]([Cl:26])=[O:17])[CH:7]=[CH:8][CH:9]=1

참가 물질

6

반응물 4

HCID 947NitrogenHCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 59291390HCID 59291390, 화합물

생성물 1

HCID 866649085-(3-Fluoro-phenyl)-thiazole-4-carbonyl chloride

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a suspension of 5-(3-fluoro-phenyl)-thiazole-4-carboxylic acid (55 mg, 0.25 mmol) in toluene (1.0 mL) was treated with a drop of DMF followed by oxalyl chloride (0.08 mL, 0.86 mmol) and the resulting yellow solution was stirred at rt for 30 min. The solvent was then removed under reduced pressure (coevaporation with toluene) to give 5-(3-fluoro-phenyl)-thiazole-4-carbonyl chloride.

후처리

  1. customThe solvent was then removed under reduced pressure (coevaporation with toluene)

출처 및 근거

ORD 기록
ord-4e270ad0e01a44af91b0a2b0171d5314
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08674111B2

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