Acetyl chloride → N-(6-Chloro-2-fluoro-3-methyl-phenyl)-acetamide
반응식
[C:1](Cl)(=[O:3])[CH3:2].[Cl:5][C:6]1[C:11]([NH2:12])=[C:10]([F:13])[C:9]([CH3:14])=[CH:8][CH:7]=1>C1(C)C=CC=CC=1>[Cl:5][C:6]1[C:11]([NH:12][C:1](=[O:3])[CH3:2])=[C:10]([F:13])[C:9]([CH3:14])=[CH:8][CH:7]=1참가 물질
4
실험 절차
Acetylchloride (2.56 mL, 36.0 mmol) is added to a mixture of 6-chloro-2-fluoro-3-methyl-aniline (5.00 g, 31.3 mmol) and toluene (200 mL), additional toluene (50 mL) is added and the mixture is heated to reflux for 3 h. Then it is cooled with an ice bath and the formed precipitate is filtered off, washed with cold toluene and dried.
후처리
- additionis added
- temperaturethe mixture is heated
- temperatureto reflux for 3 h
- temperatureThen it is cooled with an ice bath
- filtrationthe formed precipitate is filtered off
- washwashed with cold toluene
- customdried
출처 및 근거
- ORD 기록
- ord-45a7369e878740f085f49cbc7b99b5a9
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08674113B2
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