1,1'-Thiocarbonyldi-2(1H)-pyridone → N-(2,4-Dichloro-3-isothiocyanato-benzyl)-2-methyl-2-fluoro-propionamide

HRID 1189626노트

반응식

HRID 1189626 반응식
[C:1](N1C=CC=CC1=O)(N1C=CC=CC1=O)=[S:2].[NH2:17][C:18]1[C:19]([Cl:33])=[C:20]([CH:29]=[CH:30][C:31]=1[Cl:32])[CH2:21][NH:22][C:23](=[O:28])[C:24]([CH3:27])([F:26])[CH3:25]>O.O1CCOCC1>[Cl:33][C:19]1[C:18]([N:17]=[C:1]=[S:2])=[C:31]([Cl:32])[CH:30]=[CH:29][C:20]=1[CH2:21][NH:22][C:23](=[O:28])[C:24]([CH3:25])([F:26])[CH3:27]

참가 물질

5

반응물 2

HCID 8531621,1'-Thiocarbonyldi-2(1H)-pyridoneHCID 67957110N-(3-Amino-2,4-dichloro-benzyl)-2-methyl-2-fluoro-propionamide

생성물 1

HCID 86666461N-(2,4-Dichloro-3-isothiocyanato-benzyl)-2-methyl-2-fluoro-propionamide

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매2회

실험 절차

1,1′-Thiocarbonyldi-2-pyridone (1.21 g, 5.2 mmol) is added to a mixture of N-(3-amino-2,4-dichloro-benzyl)-2-methyl-2-fluoro-propionamide (1.32 g, 4.7 mmol) and dioxane (25 mL) and it is stirred at reflux for 2 d. The mixture is diluted with water, most of the dioxane is removed under reduced pressure and the resulting precipitate is collected by filtration, washed with water and dried.

후처리

  1. temperatureat reflux for 2 d
  2. customis removed under reduced pressure
  3. filtrationthe resulting precipitate is collected by filtration
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-201a2d394466413fafc6c04f8b76c7db
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08674113B2

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