Methanol → Methyl 2-chloro-4-(methylamino)-5-nitrobenzoate

HRID 1189685노트

반응식

HRID 1189685 반응식
S(Cl)(Cl)=O.[Cl:5][C:6]1[CH:14]=[C:13]([NH:15][CH3:16])[C:12]([N+:17]([O-:19])=[O:18])=[CH:11][C:7]=1[C:8]([OH:10])=[O:9].[CH3:20]O>>[CH3:20][O:9][C:8](=[O:10])[C:7]1[CH:11]=[C:12]([N+:17]([O-:19])=[O:18])[C:13]([NH:15][CH3:16])=[CH:14][C:6]=1[Cl:5]

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 679575072-Chloro-4-(methylamino)-5-nitrobenzoic acid

생성물 1

HCID 67957559Methyl 2-chloro-4-(methylamino)-5-nitrobenzoate

실험 절차

Thionylchloride (3.87 g, 32 mmol) is added dropwise at rt to a mixture of 2-chloro-4-methylamino-5-nitro-benzoic acid (5.00 g, 22 mmol) and 45 mL MeOH and it is stirred at reflux overnight. The mixture is cooled to rt and the precipitate is collected by filtration and dried. Yield: 5.01 g. MS m/z: 245 [M+H]+.

후처리

  1. temperatureat reflux overnight
  2. filtrationthe precipitate is collected by filtration
  3. customdried

출처 및 근거

ORD 기록
ord-17cd38c7ba6c4b629211428c8b58e90a
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08674113B2

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