Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isoquinoline-4-boronic acid → 8-Isoquinolin-4-yl-quinoxaline-5-carboxylic acid [3-(4-ethyl-piperazin-1-yl)phenyl]-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isoquinoline-4-boronic acid | HCID 3761204 | — |
| 반응물 | 3-(4-Ethylpiperazin-1-yl)aniline | HCID 22330105 | — |
| 반응물 | 8-Isoquinolin-4-yl-quinoxaline-5-carboxylic acid | HCID 66914512 | — |
| 생성물 | 8-Isoquinolin-4-yl-quinoxaline-5-carboxylic acid [3-(4-ethyl-piperazin-1-yl)phenyl]-amide | HCID 44515669 | — |
반응 단계
The title compound was prepared in analogy to the procedure described in Step 14.1 but using 3-(4-ethylpiperazin-1-yl)-aniline (Step 2.1) and 8-isoquinolin-4-yl-quinoxaline-5-carboxylic acid. The latter compound was synthesized as described in Steps 1.2-1.7 but using 4-isoquinolineboronic acid in Step 1.4. Title compound: ESI-MS: 489.2 [M+H]+; tR=11.28 min (System 2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08674099B2 |
| 출처 데이터셋 | uspto-grants-2014_03 |
| ORD ID | ord-16fca2c3a9c04b7fa577bc9040fcc38d |
| 출처 메모 | uspto-grants-2014_03 |