Pentanal → 3-Hydroxy-3-(3-(pentylamino)phenyl)propanenitrile

반응식

[OH:1][CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-])=O)[CH:7]=1)[CH2:3][C:4]#[N:5].[CH:15](=O)[CH2:16][CH2:17][CH2:18][CH3:19]>>[OH:1][CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[CH:7]=1)[CH2:3][C:4]#[N:5]

참가 물질

반응물 2

HCID 8063Pentanal

HCID 593169073-Hydroxy-3-(3-nitrophenyl)propanenitrile

생성물 1

HCID 672965943-Hydroxy-3-(3-(pentylamino)phenyl)propanenitrile

실험 절차

Hydrogenation of nitrobenzene 11 (0.8 g, 4.2 mmol) and pentanal (0.45 ml, 4.2 mmol) following method described in Example 11 gave 3-hydroxy-3-(3-(pentylamino)phenyl)propanenitrile as a light yellow oil. Yield (0.90 g, 77%).

출처 및 근거

ORD 기록: ord-2a9175a20f8c4d529232ffe6bdaca50c
출처 데이터셋: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08674137B2

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