1-Oxaspiro(2.4)heptane → 3-Hydroxy-3-(3-((1-hydroxycyclopentyl)methylamino)phenyl)propanenitrile

반응식

[O:1]1[C:3]2([CH2:7][CH2:6][CH2:5][CH2:4]2)[CH2:2]1.[NH2:8][C:9]1[CH:10]=[C:11]([CH:15]([OH:19])[CH2:16][C:17]#[N:18])[CH:12]=[CH:13][CH:14]=1>>[OH:19][CH:15]([C:11]1[CH:12]=[CH:13][CH:14]=[C:9]([NH:8][CH2:2][C:3]2([OH:1])[CH2:7][CH2:6][CH2:5][CH2:4]2)[CH:10]=1)[CH2:16][C:17]#[N:18]

참가 물질

반응물 2

HCID 6379911-Oxaspiro(2.4)heptane

HCID 593169603-(3-Aminophenyl)-3-hydroxypropanenitrile

생성물 1

HCID 672967103-Hydroxy-3-(3-((1-hydroxycyclopentyl)methylamino)phenyl)propanenitrile

실험 절차

Reaction between 1-oxaspiro[2.4]heptane and aniline 12 gives 3-hydroxy-3-(3-((1-hydroxycyclopentyl)methylamino)phenyl)propanenitrile.

출처 및 근거

ORD 기록: ord-16caf92572f84a54851deed284b4aa8e
출처 데이터셋: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08674137B2

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