(R)-Octahydro-pyrido[1,2-a]pyrazine → (R)-Octahydro-pyrido[1,2-a]pyrazin-2-yl-[8-(1H-pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl]-methanone

HRID 1190406

반응식

HRID 1190406 반응식
[NH:1]1[CH:5]=[C:4]([C:6]2[CH:22]=[CH:21][C:9]3[C:10]4[N:11]=[C:12]([C:18]([OH:20])=O)[S:13][C:14]=4[CH2:15][CH2:16][O:17][C:8]=3[CH:7]=2)[CH:3]=[N:2]1.[CH2:23]1[NH:28][CH2:27][CH2:26][N:25]2[CH2:29][CH2:30][CH2:31][CH2:32][C@H:24]12>>[CH2:23]1[N:28]([C:18]([C:12]2[S:13][C:14]3[CH2:15][CH2:16][O:17][C:8]4[CH:7]=[C:6]([C:4]5[CH:5]=[N:1][NH:2][CH:3]=5)[CH:22]=[CH:21][C:9]=4[C:10]=3[N:11]=2)=[O:20])[CH2:27][CH2:26][N:25]2[CH2:29][CH2:30][CH2:31][CH2:32][C@H:24]12

참가 물질

3

반응물 2

HCID 773775(R)-Octahydro-pyrido[1,2-a]pyrazineHCID 582038838-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid

생성물 1

HCID 58203943(R)-Octahydro-pyrido[1,2-a]pyrazin-2-yl-[8-(1H-pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl]-methanone

실험 절차

Following the procedure for 103, 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid (50.0 mg, 0.2 mmol) was reacted with (R)-octahydro-1H-pyrido[1,2-a]pyrazine (1.2 equiv) to give 197 (M+1 436.0)

출처 및 근거

ORD 기록
ord-0b6268db21124a9388c4d0879f7c0d34
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673952B2

연결된 노트

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