Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → N-Trifluoroacetyl 4-benzoylphenylalanine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methyl trifluoroacetate | HCID 9893 | — |
| 반응물 | p-benzoyl-L-phenylalanine | HCID 7020128 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | N-Trifluoroacetyl 4-benzoylphenylalanine | HCID 86605421 | 18.3% |
반응 단계
Methyl trifluoroacetate (89.6 μL, 891 μmoles) and triethylamine (104 μL, 743 μmoles) were added to a suspension of 4-benzoylphenylalanine (200 mg, 743 μmoles) in methanol (0.5 mL). The reaction was stirred vigorously for 24 h and then acidified with 1 N HCl until a pH of 2 was obtained. The mixture was added to ethyl acetate (10 mL), washed with 1 N HCl (2×10 mL), dried over MgSO4, and concentrated in vacuo to yield a white solid (49.7 mg, 136 μmoles, 18%). LRMS: not performed. 1H NMR: spectrum is consistent with the predicted structure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07098196B1 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-95720159bc9c4e74bfd87770a2679b41 |
| 출처 메모 | uspto-grants-2006_08 |