참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 4-((Morpholin-4-yl)methyl)benzonitrile | HCID 216864 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | [4-(Morpholin-4-ylmethyl)phenyl]methanamine | HCID 2795501 | 94% |
반응 단계
Under a nitrogen atmosphere, add lithium aluminum hydride (1.13 g, 29.7 mmol) to THF (50 mL) at 0° C. followed by a solution of 4-(morpholin-4-ylmethyl)-benzonitrile (2 g, 9.89 mmol) in THF (10 mL). Stir at 0° C. for 1 h and at room temperature overnight. Cool the mixture to 0° C., and carefully add water (1.15 mL). Add diethyl ether (125 mL), 3N aqueous NaOH (1.15 mL), water (3.45 mL), and stir for 1 h at room temperature. Filter the solid residue and concentrate the filtrate in vacuo to obtain the title compound as a colorless oil (1.87 g, 94%). MS (APCI+) m/z: 207 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08680091B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_03 |
|---|
| ORD ID | ord-38763a18346d4bdb8e4e4c28e7e940d1 |
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| 출처 메모 | uspto-grants-2014_03 |
|---|
