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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Potassium Carbonate → (R)-(1-Methyl-2,2,2-trifluoroethyl)-thiourea

HRID 1191079
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HRID 1191079 반응식
C([NH:9][C:10]([NH:12][C@H:13]([CH3:18])[C:14]([F:17])([F:16])[F:15])=[S:11])(=O)C1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+]>CO.O>[CH3:18][C@@H:13]([NH:12][C:10]([NH2:9])=[S:11])[C:14]([F:17])([F:16])[F:15]
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참가 물질

5

반응물 2

HCID 11430Potassium CarbonateHCID 58495475(R)-1-Benzoyl-3-(1-methyl-2,2,2-trifluoroethyl)-thiourea

생성물 1

HCID 58495653(R)-(1-Methyl-2,2,2-trifluoroethyl)-thiourea수율 74.9%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

Dissolve (R)-1-benzoyl-3-(1-methyl-2,2,2-trifluoroethyl)-thiourea (6.2 g, 22.5 mmol) in methanol and add a solution of potassium carbonate (13.8 g, 100 mmol) in water (30 mL). Stir vigorously at room temperature overnight. Evaporate to dryness, dissolve residue in hot water (ca. 100 mL) and filter the resulting white crystals. Cool filtrate to 0° C., seed with crystals from hot water filtration, filter and collect resulting white crystals to obtain the desired intermediate (2.9 g, 74%). MS (ES+) m/z: 173 (M+H)+.

후처리

  1. customEvaporate to dryness
  2. dissolutiondissolve residue in hot water (ca. 100 mL)
  3. filtrationfilter the resulting white crystals
  4. filtrationCool filtrate to 0° C., seed with crystals from hot water filtration
  5. filtrationfilter
  6. customcollect
  7. customresulting white crystals

출처 및 근거

ORD 기록
ord-c717b8cd54c340759867ca97ec07b607
출처 데이터셋
uspto-grants-2014_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08680091B2

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