3-Chlorothiophenol → 1-[5-(3-Chlorophenylsulfanyl)-4-nitro-2-thienyl]ethanone

반응식

Cl[C:2]1[S:6][C:5]([C:7](=[O:9])[CH3:8])=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11].[Cl:13][C:14]1[CH:15]=[C:16]([SH:20])[CH:17]=[CH:18][CH:19]=1>>[Cl:13][C:14]1[CH:15]=[C:16]([S:20][C:2]2[S:6][C:5]([C:7](=[O:9])[CH3:8])=[CH:4][C:3]=2[N+:10]([O-:12])=[O:11])[CH:17]=[CH:18][CH:19]=1

참가 물질

반응물 2

HCID 162573-Chlorothiophenol

HCID 5211051-(5-Chloro-4-nitrothiophen-2-yl)ethan-1-one

생성물 1

HCID 469319561-[5-(3-Chlorophenylsulfanyl)-4-nitro-2-thienyl]ethanone

실험 절차

Prepared according to the procedure described as in Step B for example 1 from 1-(5-Chloro-4-nitro-2-thienyl)ethanone (0.502 g, 2.45 mmol) and 3-chlorobenzenethiol (0.353 g, 2.45 mmol). The title compound was obtained as a yellow solid (0.476 g, 62% yield). 1H NMR (300 MHz, CDCl3) δ: 8.08 (1H, s), 7.68 (1H, m), 7.45-7.60 (3H, m), 2.49 (3H, s).

후처리

customPrepared

출처 및 근거

ORD 기록: ord-01c1ca3c6b5040ae8b21aa0b21fa499b
출처 데이터셋: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08680139B2

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