Methyl 5-chloro-4-nitrothiophene-2-carboxylate → Methyl 5-((3,5-dichloro-2,6-dimethylpyridin-4-yl)thio)-4-nitrothiophene-2-carboxylate
반응식
Cl[C:2]1[S:6][C:5]([C:7]([O:9][CH3:10])=[O:8])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[Cl:14][C:15]1[C:16]([CH3:24])=[N:17][C:18]([CH3:23])=[C:19]([Cl:22])[C:20]=1[S-:21].[Na+]>>[Cl:14][C:15]1[C:16]([CH3:24])=[N:17][C:18]([CH3:23])=[C:19]([Cl:22])[C:20]=1[S:21][C:2]1[S:6][C:5]([C:7]([O:9][CH3:10])=[O:8])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12]참가 물질
3
실험 절차
Prepared according to the procedure described for example 18 from methyl 5-chloro-4-nitrothiophene-2-carboxylate (300 mg, 1.36 mmol) and sodium 3,5-dichloro-2,6-dimethylpyridine-4-thiolate (282 mg, 1.36 mmol) from above. The titled product was obtained as a solid (380 mg, 77% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.27 (1H, s), 3.83 (3H, s), 2.07 (3H, s), 2.05 (3H, s).
후처리
- customPrepared