Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butanol → 3-azido-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-propanoic acid, ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butanol | HCID 6386 | — |
| 반응물 | Ethyl Acrylate | HCID 8821 | — |
| 반응물 | Potassium | HCID 5462222 | — |
| 반응물 | 3-Azido-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one | HCID 10932520 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Tert-butanol tetrahydrofuran | HCID 66775918 | — |
| 생성물 | 3-azido-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-propanoic acid, ethyl ester | HCID 86749790 | — |
반응 단계
A solution of 3-azido-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one [prepared as described by Watthey et al., J. Med. Chem., 28, p. 1511-15156 (1985)] in tetrahydrofuran/tert-butanol was cooled to 0° C. and treated with ethyl acrylate and 1N tert-butanol, potassium salt/tetrahydrofuran according to the procedure of Example 40 part (a) affording 3-azido-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-propanoic acid, ethyl ester as a syrup. TLC (ethyl ether:hexane, 1:1) Rf =0.45.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723457 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-1a4951c4532f4cb2bdd53951628d0ded |
| 출처 메모 | uspto-grants-1998_03 |